The overall goal of our research is to develop safe, economically and environmentally sustainable chemical and biological processes through the synergistic use of advanced computational modelling and optimisation methods and process data. Our vision of process systems engineering has a strong focus on rigorous computation to predict the performance at scale of both existing and novel technology and empower decision-making, and we work in close collaboration with experimentalists. We furthermore develop software tools that implement these methods to ensure their dissemination (https://github.com/omega-icl).